Red Light Therapy in O’Fallon

Experiencing a red light therapy session creates a pause in your day. It grants you the opportunity to take a breath and breathe. For thirty minutes, you can escape the hustle and bustle of your day to appreciate all the great things coming your way.

We all want to be healthy, but wellness is more than eating, sleeping, and exercising. It is taking the time to celebrate our seconds. The world moves like a whirlwind; your red light therapy session is an opportunity to slow things down. It is a means to escape the murky waters of negativity and encourage your spirit to feel free.

Red light therapy is more than 30 minutes of peace and ease; it also offers an array of holistic benefits. Continue reading, or schedule a session today to see why so many love this spectacular service.

Your Red Light Therapy Treatment Session

You will experience your session in a comfy private room where you can relax, destress, and rejuvenate. The outside world will melt away as the red and near-infrared light safely penetrates your cells, encouraging you to feel the peace and ease you need.

At the start of your session, you may enjoy a hot cup of green tea to encourage a welcoming environment for the light rays to enrich your existence. At the end of your red light therapy session, we will welcome you back with a bottle of water and exquisite chocolates as a reward for taking care of yourself.

When receiving your red light therapy (RLT), you will enjoy the privacy and comfort of your own room. You’ll have a designated area to store your clothing and get dressed, with spa towels and a bottle of water readily available. The soothing and serene ambiance encourages you to breathe and take it easy. You will be offered a cup of green tea before your session.

Can I Get a Massage and a Red Light Therapy Session?

Yes of course, combine your Pain Management Massage with a 15 minutes red light therapy to maximize your results.

If you schedule a red light therapy session after a massage, we suggest adding a Full-body Hot Towel Treatment to  your session. This helps remove excess oil that may inhibit light penetration. 

How Often Can I Get Red Light Therapy?

There is no research indicating the maximum number of red light therapy sessions someone can safely receive. Due to the lack of research in this area we suggest you observe how you feel after a session and adjust accordingly. With that in mind, mild redness, warmth, or dryness may occur temporarily after a session.

Some individuals may experience fatigue if sessions are too long or too frequent. Everyone responds differently. While many individuals tolerate red light therapy well, those with photosensitivity, certain medical conditions, or who take photosensitizing medications should consult a healthcare provider before beginning treatment.

My Journey with Red Light Therapy: From Skeptic to Believer

Red light therapy is gaining popularity as a pain management tool to reduce inflammation. Many use it as an alternative treatment for tissue repair, photoaging and photodamaged skin, acne lesions and scars. Others use it to assist in muscle recovery, improve athletic performance, mental clarity, and aid in relaxation and sleep.

My first experience with red light therapy was when I was struggling through the pain of a pinched nerve. My then-significant other offered to use her red light wand on my back and neck. At first, I didn’t want to try it because I am skeptical of new things, but I said yes. I am glad I did; within 20 minutes, the red light wand reduced my eight-level pain to two! I was awed by the results.

After experiencing my near-miraculous pain relief results, I have used red light therapy as an integral component of my wellness routine, and now we are offering it at Jennifer Brand Spa. – Shawn White

History of Red Light Therapy

Red light therapy (RLT), also known as low-level laser therapy (LLLT) or photobiomodulation (PBM), is a non-invasive approach that delivers red and near-infrared light to the body. Research suggests it may support cellular function, relaxation, and overall well-being.

PBM was first discovered nearly 50 years ago by Endre Mester in Hungary. Initially referred to as low-level laser therapy, early research utilized ruby lasers (694 nm) and helium-neon (HeNe) lasers (633 nm) as primary light sources. PBM is the preferred terminology, as “low-level” was considered subjective and misleading. Additionally, research has demonstrated that non-coherent light-emitting diodes (LEDs) can achieve therapeutic effects comparable to those of lasers, negating the necessity of laser-based devices.[1]

Later, red light therapy research was used by NASA to explore its benefits to stimulate plant growth and wound healing for astronauts in space. NASA’s research into red light therapy initially focused on plant growth and wound healing for astronauts in space. Over time, RLT has also been explored as a complementary approach in photodynamic therapy (PDT), a technique where light activates a photosensitizing compound to target specific cells. While PDT is used for conditions like skin cancer and psoriasis, RLT itself does not involve photosensitizing agents but has been studied for its potential role in skin health and cellular function.

We genuinely want to help you achieve the wellness you need. Our Elite, Premium, and Essential red light therapy memberships are the best options for optimizing your wellness results. However, for those who would like to pay as you go, our 30-minute red light sessions are $29.99 each.

What Kind of Red Light Therapy Device Do We Use?

Our facility uses an FDA Class II-cleared device [31] that delivers red light (660nm) and near-infrared (NIR) light (850nm). These wavelengths have been studied for their potential to support skin health, relaxation, and recovery. Each session includes exposure to both red and near-infrared light at these wavelengths.

What is clinical-grade irradiance?

Light wavelengths measure in nanometers (nm) and they exhibit varying degrees of absorption in the body based on their length. Shorter wavelengths, such as blue light, are more energetic, while longer wavelengths, such as red light, penetrate deeper into tissues at a slower rate.

• Violet: 380–450 nm
• Blue: 450–495 nm.
• Green: 495–570 nm.
• Yellow: 570–590 nm.
• Orange: 590–620 nm.
• Red: 620–750 nm

Each color induces specific biological effects based on wavelength; blue light (approximately 450–495 nm) helps boost attention, reaction times, and mood. While beneficial during the day, it may disrupt sleep patterns at night. Additionally, it has antibacterial properties that help kill Propionibacterium in treating acne, while green light (around 495–570 nm) is commonly used for migraine relief, fibromyalgia, and chronic musculoskeletal pain. Amber light (570–590 nm) is being explored for its potential to support relaxation, reduce eye strain, and calm sensitive skin.

Extensive research suggests that red light (620–750 nm) and near-infrared (NIR) light (810–850 nm) are among the most widely studied wavelengths for their potential effects on skin, relaxation, and cellular function. When delivered to bare skin through devices equipped with high-intensity LED bulbs, red light is absorbed primarily by the upper layers of the skin. In contrast, NIR light penetrates more deeply, reaching underlying tissues, including connective tissue and bone.

Red light is absorbed by mitochondria, the energy-producing centers of cells. Research suggests that this light interacts with cytochrome c oxidase, a key enzyme involved in cellular respiration. This interaction may enhance mitochondrial efficiency, supporting the body’s natural production of adenosine triphosphate (ATP)—a molecule essential for cellular energy.

What Researchers Are Exploring

The following research articles present conclusions from peer-reviewed scientific studies on Low-Level Laser Therapy (LLLT) and Red Light Therapy (RLT). These findings summarize what researchers have observed in clinical and laboratory settings. This list is for informational purposes only and does not constitute medical advice. The inclusion of a study does not imply endorsement or guarantee of results. Individuals should consult healthcare professionals before considering any therapy.

Red light therapy is not intended to diagnose, treat, cure, or prevent any disease. It is not a substitute for professional medical advice. Consult your doctor before beginning any new treatment.

🧖‍♀️ Skin Health & Rejuvenation

Some people apply green tea to their face and body before a red light therapy treatment, citing green tea is rich in EGCG, an antioxidant that has been studied for its potential to support skin rejuvenation and healing. Some research suggests that applying green tea before light therapy may enhance skin responsiveness to light and provide antioxidant support. [4,5]

Researchers are exploring how red light therapy interacts with skin health, including its potential role in sebum regulation and moisture retention. Some studies have investigated whether red light therapy affects Propionibacterium acnes (P. acnes) by absorbing light and influencing bacterial function.

Scientists are studying whether red light therapy can play a role in skin inflammation. Researchers are also looking into its possible effects on collagen and elastin, two proteins that help keep skin firm and strong. Another area of study is how red light therapy might support the body’s natural healing process, including wound care and scar recovery. [26]

• ✨ Fine Lines & Wrinkles – In studying how RLT interacts with collagen production, some researchers believe it may help improve the appearance of fine lines, wrinkles, and skin texture by supporting collagen density. [6,7]
• 🩹 Skin Healing & Scarring – Researching its potential in wound recovery, some research indicates RLT may support skin healing and appearance, including acne scars, hypertrophic scars, and burns. [7,8]
• 🌞 Melasma & Sun Damage – Some studies indicate it may have the potential to help manage melasma and enhance resistance to future UV exposure. [37, 38]
• 🛡️ Skin Protection – May contribute to skin protection by reducing oxidative stress from UV exposure. [7]
• 🎨 Skin Pigment Balance – Has been explored for its potential to support pigment balance in conditions like vitiligo. [7]
• 🌿 Inflammation & Skin Conditions – May assist in managing inflammatory skin concerns, including psoriasis and acne. [7,8]
• 💎 Collagen & Skin Renewal – Some research indicates RLT may encourage collagen production while aiding in the renewal of damaged collagen fibers. [7]
• 🧴 Oily Skin & Breakouts – May help regulate sebum production and support clearer skin. [16,17,18,26]

🏥 Wound Healing, Post-Surgical Recovery & Lymphatic Support

Red light therapy has been explored for its potential to support post-surgical lymphatic drainage and reduce scar tissue formation. After surgery, the body rapidly produces collagen to close wounds, sometimes leading to thick, less elastic scar tissue that can restrict movement and impair natural lymphatic flow.

Research suggests that red light therapy may promote healthier, more flexible skin by stimulating collagen-producing cells, which could help in softening scars, restoring mobility, and improving overall skin health. [2]

Additionally, red light therapy has been studied for its role in supporting pain relief and mobility in individuals with Axillary Web Syndrome (AWS), a painful condition that can develop post-mastectomy due to lymphatic disruptions. [74]

• 🏥 Healing After Surgery – Studies suggest RLT may support the body’s natural healing process following surgery. [2]
• 🩹 Wound Healing & Pain Relief – May play a role in supporting wound healing, pain relief, and reducing inflammation. [7,8,9,10,19,20]
• 🦴 Bone & Tendon Recovery – Has been studied for its potential to aid in bone and tendon recovery. [9]

Learn More About Red Light Therapy for Lymphedema

🏋️‍♂️ Muscle Recovery & Physical Performance

• 💪 Exercise Performance – May assist in muscle performance and recovery after exercise. [11]
• 🔥 Muscle Soreness (DOMS) – Has been shown to reduce the effects of Delayed Onset Muscle Soreness (DOMS). [11]
• 🦾 Inflammation & Recovery – May help reduce muscle inflammation and oxidative stress, supporting post-exercise recovery. [11]

🦴 Joint, Nerve & Pain Support

• 🎾 Tennis Elbow, Golfer’s Elbow & Carpal Tunnel – Has been researched for its potential to support pain management and grip strength in conditions like tennis elbow, golfer’s elbow, and carpal tunnel syndrome. [39, 40, 41, 42]
• 🦶 Nerve Pain (Neuropathy) – May assist in easing neuropathy-related discomfort. [43, 44, 45]
• 🚶 Foot & Heel Pain (Plantar Fasciitis) – May aid in pain relief and mobility improvements for individuals with plantar fasciitis. [53, 54, 55, 56]
• 🌸 Menstrual Cramps – May provide relief for menstrual discomfort. [61, 62, 63]
• 🏥 Pelvic Pain – Has been studied as a potential therapy for chronic pelvic pain. [64]

🧠 Brain Health & Cognitive Function

• 🧠 Alzheimer’s & Parkinson’s – Research is looking into how it could support brain function in these conditions. [46, 47, 48, 49, 50]
• 🧩 Autism & Neurodevelopment – Studies are investigating if it plays a role in brain development and neurodiversity. [70, 71, 72, 73]
• 🌙 Memory, Mood & Sleep – Some research suggests it could help with cognitive function, emotional balance, and sleep quality. [10]
• 🛡️ Brain Cell Health – Scientists are studying if it can help protect brain cells from oxidative stress. [10]
• 🔬 Brain & Immune System – Studies are looking at how it may be linked to immune system regulation in the brain. [10]
• ❤️ Circulation & Oxygen Flow – Research is exploring whether it supports healthy blood flow and oxygenation in the brain. [10]

🫁 Immune & Respiratory Support

• 🤧 Seasonal Allergies – Studies are looking into whether it can help with nasal comfort during allergy season. [21, 22]
• 🔥 Shingles & Nerve Pain – Research suggests it may play a role in easing discomfort from shingles and post-herpetic neuralgia. [65, 66]
• 💋 Cold Sores – May accelerate the healing process of cold sores (herpes simplex labialis). [67, 68, 69]
• 🦠 Viral Warts – Scientists are exploring its potential role in addressing viral warts. [51, 52]

🦋 Thyroid, Reproductive & Hormonal Health

Scientists are studying how red and near-infrared light therapy might help with reproductive health. A small study looked at its effects on age-related infertility, focusing on women who had struggled with multiple failed IVF treatments, miscarriages, and trouble with embryo implantation.

In one case series, three women underwent weekly to bi-weekly red light therapy sessions after struggling to conceive for over two years. Remarkably, all three became pregnant and delivered healthy babies. While this study was small and further research is needed, it highlights an area of growing interest in non-invasive fertility support. [13]

• 🦋 Hashimoto’s & Thyroid Function – Has been explored for its potential to support thyroid function in individuals with Hashimoto’s. [57, 58, 59, 60]

⚡ Cellular & Circulatory Function

👁️ Eye Health & Vision Support

Red light therapy is being explored as a potential tool for supporting retinal health, including in conditions like glaucoma and other retinal diseases. Some research suggests that prolonged exposure to blue light from screens and electronic devices may contribute to mitochondrial stress and retinal cell damage. This damage can impact the retinal ganglion cells, which play a crucial role in vision.

Preliminary studies indicate that red light may help support eye health by stimulating cytochrome c oxidase, a key enzyme in mitochondrial function. This process may promote cell repair, reduce oxidative stress, and help regulate inflammation in the retina. While further research is needed, anecdotal reports suggest that consistent red light exposure may have potential benefits for visual function. [12]

Beyond Pain Relief: How Far Can Red Light Therapy Go?

👉 Ongoing research continues to explore new applications of red light therapy. While more studies are needed, its potential across multiple areas of health and wellness makes it an exciting area of scientific investigation.

Best Serums for Red Light Therapy – Vitamin A, C, & E

Would you like to enhance the benefits of your red light therapy session? Using a serum after your session may help support your skin’s natural recovery process and hydration. It’s best to avoid applying serums, lotions, or creams before your RLT session, as some ingredients may create a barrier that affects light absorption or cause sensitivity when exposed to red or near-infrared light.

Vitamin C serum

Vitamin C is the most abundant antioxidant in human skin and helps protect it from damage. It works alongside other antioxidants to neutralize harmful molecules called reactive oxygen species (ROS), which are produced when the skin is exposed to UV light. These ROS include substances like superoxide ions, peroxide, and singlet oxygen, which can cause skin damage and aging. Additionally, UV exposure lowers Vitamin C levels in the skin, making it important to replenish through diet or skincare products.

Vitamin C is essential for making collagen, the protein that keeps skin firm and strong. It not only increases the amount of collagen but also improves its quality and structure. It helps by acting as a co-factor for enzymes (prolysyl and lysyl hydroxylase) that stabilize and strengthen collagen fibers. It also triggers a process called lipid peroxidation, which produces a substance (malondialdehyde) that activates collagen genes, encouraging more collagen production.

Additionally, Vitamin C helps by directly turning on collagen-producing genes and stabilizing collagen-building molecules (procollagen mRNA), making sure collagen is formed properly. A lack of Vitamin C leads to scurvy, a disease caused by poor collagen production, resulting in weak skin, bleeding gums, and slow wound healing. Studies show that applying Vitamin C to the skin (topically) boosts collagen production, helping both young and aging skin stay firm and healthy.

Vitamin C is available in creams, serums, and patches, but serums are the most effective form because they contain active Vitamin C in a nearly colorless state. However, Vitamin C is unstable and can turn yellow when exposed to light, as it oxidizes into Dehydro Ascorbic Acid (DHAA). To keep it stable, skincare products must have a pH lower than 3.5, which also helps it absorb better into the skin.

The effectiveness of Vitamin C serums increases with concentration but only up to 20%—anything higher doesn’t add extra benefits. Once applied, Vitamin C stays active in the skin for about 4 days, meaning regular use is important for long-lasting protection. Since UV light reduces Vitamin C levels in the skin, it’s best to apply Vitamin C after sun exposure, not before. Studies show that combining Vitamin C with tyrosine and zinc makes it 20 times more effective than using Vitamin C alone. [30]

• ✔ For better absorption, Vitamin C serums typically have a pH below 3.5
• ✔ Studies suggest that Vitamin C serums are most effective up to a concentration of 20%, with no additional benefits at higher levels.

Vitamin E serum

Vitamin E is a powerful antioxidant that helps protect the skin from environmental stressors, such as UV radiation and pollution. These stressors generate free radicals—unstable molecules that can contribute to premature aging. When paired with Vitamin C, Vitamin E enhances antioxidant protection by helping neutralize these free radicals before they damage skin cells. Free radicals contribute to skin aging by damaging cells. Vitamin E helps reduce pigmentation & dark spots, boosting collagen production for firmer skin, and improves oil gland function for better moisture retention.

Anti-Inflammatory Benefits of Vitamin E: Vitamin E may reduce inflammation and protect against UV damage. It naturally occurs as tocopherols, with alpha-tocopherol being the most potent. In its natural form (unesterified α-tocopherol), it is a powerful antioxidant that supports overall skin health.

Vitamin E is oil-soluble, making it ideal for creams, serums, and other skincare products. It helps moisturize, strengthens skin membranes, and protects polyunsaturated fatty acids from oxidation. It is easily absorbed into skin and hair and stabilizes skin structure, improving hydration and elasticity.

Additionally, vitamin E & vitamin C work together! Vitamin E traps free radicals to prevent skin damage. Vitamin C helps regenerate Vitamin E, making them more effective together. This combination provides stronger antioxidant protection for the skin. [29]

Vitamin A serum

Vitamin A is available in two primary forms: provitamin A carotenoids (found in plant-based foods) and preformed vitamin A (such as retinol, found in animal sources and skincare formulations). Research suggests that preformed Vitamin A (retinol) is more bioavailable, making it a preferred option for supplementation and topical use. Since Vitamin A plays a role in collagen production and skin regeneration, its combination with red light therapy may support enhanced skin renewal and repair. However, Vitamin A levels vary among individuals, and deficiencies can affect skin function and overall response to treatments like RLT. [76]

Vitamin A plays a role in skin renewal and may help encourage the growth of new blood vessels (neoangiogenesis), supporting oxygen and nutrient delivery to tissues. When used alongside red light therapy, it may contribute to a more supportive environment for skin recovery and regeneration. Retinoids, a form of Vitamin A, are often used in skincare for their potential to enhance cell turnover and collagen production. [28]

Vitamin A may help balance the immune system by affecting cytokines, which are molecules that control inflammation and healing. A review of studies found that Vitamin A lowered certain inflammatory markers (IL-17, IFN-γ) and increased anti-inflammatory ones (TGF-β, FOXP3), especially in people with autoimmune conditions like multiple sclerosis. Since red light therapy has also been studied for its potential effects on inflammation and healing, using Vitamin A alongside RLT may support skin health and recovery. While more research is needed, this combination could be worth exploring for overall wellness. [75]

Since RLT helps boost collagen and improve skin health, applying Vitamin A after a red light therapy session may enhance these effects. However, research shows that retinol breaks down when exposed to light, so it should be used after RLT rather than before. Since both RLT and retinol speed up skin renewal, they may increase sensitivity and dryness if not used properly. To maximize benefits, retinol should be applied after RLT, followed by a moisturizer to help maintain skin hydration. [77]

Red Light Therapy Warnings, Precautions and Contraindications

Currently, there is no direct research evidence indicating that low-level laser therapy (LLLT) or red light therapy (RLT) harms individuals with photosensitivity. A 2014 review by Kerstein and Lister found no reported adverse effects of laser treatments in patients taking photosensitizing medications. [36] We erred on caution; even though red light therapy does not contain ultraviolet light, we advise our clients with photosensitivity to consult a medical professional before receiving RLT.

Potential Contraindications

Following FDA guidelines, we advise individuals with open wounds or lesions, active implantables (e.g., pacemakers or defibrillators), or metallic implants not to receive red light therapy in these areas. [31]

Do you need eye protection for red light therapy?

Though research indicates improved eye health associated with red light therapy treatment, we and the FDA suggest wearing eye protection throughout the session.[12, 31]

Conditions That May Be Aggravated by Red Light Therapy

Lupus

Individuals with Lupus should consult with their physician before receiving red light therapy. Most people with Lupus have photosensitivity, which means their skin is extra sensitive to sunlight and certain indoor lights that give off ultraviolet (UV) rays. Anyone can get skin damage from too much UV exposure, but people with photosensitivity react more strongly.

UV rays damage cells in the body, and normally, the immune system clears away these damaged cells to keep us healthy. In Lupus, the immune system doesn’t clear out dead cells properly. Instead, it attacks healthy cells, leading to rashes, inflammation, and other lupus symptoms. While Red Light Therapy does not contain ultraviolet (UV) radiation, people with Lupus can be hyper-sensitive to light. While some studies suggest RLT may reduce inflammation, which could help with joint pain, fatigue, and skin healing, we strongly suggest seeking advice from a medical professional before receiving a Red Light Therapy treatment. Additionally, if someone with Lupus is taking photosensitizing medications, RLT could cause irritation or discomfort. [25]

For those with Lupus we suggest:

• ✅ Check with your rheumatologist or dermatologist before trying RLT.
• ✅ Test a small area of skin first and monitor for any reactions.
• ✅ Limit session time if you’re unsure.

Cancer

Individuals with cancer should consult with their physician before receiving red light therapy. The primary concern people have with RLT is its ability to stimulate cell growth, theorizing this may encourage tumor growth. However, no conclusively strong evidence indicates that red light therapy causes tumors to grow faster or slower. Additional research suggests RLT may be a beneficial treatment of melanomas due to its ability to interact with cytochrome c oxidase, which may cause cancer cells into self-destruction (apoptosis) or stop them from spreading (metastasis).

In vitro, red light therapy has slowed melanoma cell growth, increased oxidative stress and apoptosis, and activated p53. This protein helps control cell division and prevent cancer.  In animal studies, it has reduced melanoma tumor growth and boosted immune activity in the tumor environment, helping the body to fight cancer. [14] While this research is exciting, more research is required to understand how RLT affects cancer cells and whether it could be an effective treatment method.

Epilepsy

Individuals with epilepsy should consult with their physician before receiving Red Light Therapy. People with epilepsy or who experience photosensitive seizures may be exposed to bright, pulsed, or flickering light in an RLT session, which may put them at risk.

Researchers are exploring red and near-infrared light therapy for the treatment of epilepsy. Though potentially risky, it is lower risk compared to the medication, surgeries, and serious side effects of standard treatment. Early studies in animals with epilepsy show that photobiomodulation may help by targeting mitochondria. In theory, this will help reduce abnormal brain activity and protect brain cells from damage and death, two major issues faced by people with epilepsy. Why Is RLT promising? It is a non-drug, non-invasive treatment with easy-to-use devices that has an excellent safety record with little to no side effects. [15]

Pregnancy

Pregnant women should consult with their physician before receiving red light therapy. No strong evidence suggests harm, but there is limited research on RLT during pregnancy.

Recent Use of Photosensitizing Medications

If you’re taking medications that cause photosensitivity, you might wonder whether red light therapy could trigger a reaction. While RLT does not contain UV light (a common cause of drug-induced skin sensitivity), some medications make your skin more reactive to all types of light, including visible red and near-infrared light. Understanding how these drugs work can help you make an informed decision and prevent unwanted reactions.

Medicines like Tetracyclines, Retinoids, NSAIDs, Diuretics, antifungals, or chemotherapy can cause photosensitivity, but in many cases, the incident rate is very low. Medications marked with ⚠️ are known to be strong photosensitizers; therefore, if you use them, we suggest consulting with a medical professional before receiving red light therapy.

⚠️Amiodarone, Chlorpromazine, Doxycycline, Hydrochlorothiazide, Nalidixic acid, Naproxen, Piroxicam, Tetracycline, Thioridazine, and Vemurafenib, Voriconazole.

A recent meta-analysis on photosensitivity [35] reported how often these medications caused light-sensitive reactions in users:

• Amiodarone (heart medication): 10–75% of users experience photosensitivity.
• Voriconazole (antifungal): has an unknown incidence rate.
• Chlorpromazine (antipsychotic): 2–3% of users experience photosensitivity.
• Lomefloxacin (antibiotic): 1–3% of users experience photosensitivity.
• Naproxen (pain reliever): has an unknown incidence rate.
• Doxycycline (antibiotic): 4–42% of users experience photosensitivity.
• Hydrochlorothiazide (blood pressure medication): 0.001–0.01% of users experience photosensitivity.
• Vemurafenib (cancer drug): 12–63% of users experience photosensitivity.

⚠️Tetracyclines

People who are currently using or have previously used Tetracyclines should consult a doctor before undergoing red light therapy.

Tetracyclines are broad-spectrum antibiotics used to treat various bacterial infections, including chlamydia, mycoplasma, rickettsia, and certain parasites. They are one of the most well-known drug classes associated with photosensitivity, meaning they can make the skin more sensitive to sunlight.

Tetracycline and doxycycline have been reported to cause sunburn-like reactions, ranging from mild redness and burning in sun-exposed areas to more severe sun-induced rashes (photodermatitis). In rare cases, they can also trigger solar urticaria (hives from sunlight), actinic granuloma (skin inflammation), and lichenoid reactions (a lichen planus-like rash).

In addition to skin reactions, tetracyclines can cause nail damage (photo-onycholysis), where the nails detach from the nail bed due to sun exposure. This has been reported with tetracycline, doxycycline, minocycline, and lymecycline. Doxycycline is particularly notable for causing severe nail damage in children, sometimes affecting all 20 nails—even at low doses (20 mg/day). Importantly, these nail changes can appear up to two weeks after sun exposure.

The photosensitivity caused by doxycycline is thought to be due to UVA1 radiation (340–400 nm) and appears to be dose-dependent. Studies from the UK found that 3% of people taking 100 mg of doxycycline experienced phototoxicity. The incidence increased to 20% at 150 mg and 42% at 200 mg. However, the actual frequency of these reactions is unclear, as they are often underreported, with estimated incidence rates for doxycycline ranging from 3% to 16% in different studies.

There has also been research on the potential link between tetracycline use and skin cancer. A large U.S. study found that tetracycline use increased the risk of basal cell carcinoma (BCC) by 11%. Still, no significant increase was observed for squamous cell carcinoma (SCC) or melanoma. [23, 34]

There’s no research showing that RLT harms people with photosensitivity. However, if you’ve taken tetracycline antibiotics, you should talk with your doctor before trying red light therapy.

• ⚠️ doxycycline (Acticlate®, Adoxa®, Doryx®, Vibramycin® and others)
• minocycline (Amzeeq®, Arestin®, Ximino®, Solodyn® and others)
• ⚠️tetracycline (Acticlate®, Adoxa®, Doryx®, Vibramycin® and others)
• lymecycline
• sarecycline (Seysara®)
• demethylchlortetracycline
• chlortetracycline
• metacycline.
• Demeclocycline
• Rolitetracycline
• Eravacycline (Xerava®)
• Omadacycline (Nuzyra®)
• There may be Tetracyclines not mentioned on this list, if you are taking medicine for the following health conditions please consult with your physician to ensure you can receive red light therapy.
  • Acne, Actinomycosis, Amebiasis, Anaplasmosis (tick bite infection), Chlamydia, Early Lyme disease, Ehrlichiosis, Legionnaires’ disease, Leptospirosis, Melioidosis, Pelvic inflammatory disease, Pneumonia, bacterial respiratory tract infection, Rickettsial infections, Staph infections, Syphilis, Traveler’s diarrhea, Tularemia, Whipple’s disease.
  • Additionally, Tetracyclines may be prescribed to individuals with anthrax and food poisoning if they cannot take penicillin. [24]

Retinoids

People who are currently using or have previously used retinoids should consult a physician before undergoing red light therapy.

Topical retinoids (adapalene, isotretinoin, tretinoin, trifarotene) are used to treat mild to moderate acne. They are a first-line treatment for clogged pores (comedonal acne) and inflammatory acne. Retinoids are also reduced to acne scars and help with post-inflammatory hyperpigmentation (dark spots after acne), especially in darker skin tones.

Retinoids like tretinoin, isotretinoin, adapalene, and trifarotene have various dermatological uses. When used long-term (over six months), tretinoin can help reduce freckles, sunspots, fine lines, clogged pores, fragile skin, and precancerous lesions (actinic keratoses) caused by sun damage. It is also commonly combined with skin-lightening ingredients to treat melasma (dark patches on the skin).

In addition to acne treatment, topical isotretinoin, tretinoin, and adapalene have been effective in improving localized Darier disease, a rare skin disorder. Other topical retinoids serve specific dermatological purposes.

Alitretinoin is FDA-approved for Kaposi sarcoma (an HIV-related skin cancer), while bexarotene is used for cutaneous T-cell lymphoma. Tazarotene is prescribed for facial acne, post-inflammatory hyperpigmentation, chronic plaque psoriasis, and sun damage. Trifarotene is approved for treating various forms of ichthyosis (thick, scaly skin disorders), including X-linked ichthyosis, epidermolytic ichthyosis, and erythrokeratoderma variabilis. [32]

Even though there is no evidence that red light therapy harms people with photosensitivity, knowing these differences can help you understand the potential side effects. If you are on either medication, it’s wise to discuss red light therapy with your doctor to ensure you take the proper precautions.

NSAIDs

⚠️Piroxicam, ⚠️Naproxen

Since NSAIDs can have the potential of making your skin more sensitive to light, talk to your doctor before trying red light therapy to avoid any possible reactions.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of medications used to relieve pain, inflammation, and fever. Some NSAIDs have been reported to cause photosensitivity, meaning they can make the skin more sensitive to sunlight. While NSAIDs may make the skin more sensitive to sunlight, leading to photosensitivity reactions, scientists don’t fully understand how this happens, and the symptoms don’t always match typical phototoxic or photoallergic reactions. While some NSAIDs can directly cause phototoxic reactions, others may trigger skin sensitivity in a different way that still isn’t fully understood. [33]

In the past, benoxaprofen was one of the worst offenders, with over 50% of its side effects related to photosensitivity, sometimes leading to severe skin damage. Due to these risks, it was removed from the market in the early 1980s.

Piroxicam, still available today, has been linked to blistering (vesiculobullous), eczema-like rashes, and lichen-like skin reactions. Among the commonly used NSAIDs, naproxen appears to be the most likely to cause photosensitivity, often leading to pseudoporphyria (skin fragility and blistering), sunburn-like reactions, and rashes like erythema multiforme.

Other NSAIDs with reported photosensitivity reactions include oxaprozin, nabumetone, ampiroxicam, tiaprofenic acid, sulindac, and meclofenamate sodium. Diclofenac has been linked to photo-onycholysis, a condition where sunlight causes nail damage but not skin rashes.

Ibuprofen is not considered a strong photosensitizer, with only one reported case of photosensitivity. However, later tests showed that this patient had increased UVA sensitivity while taking ibuprofen. Celecoxib, a type of NSAID known as a COX-2 inhibitor, has also been linked to photoallergic reactions and pseudoporphyria.

There is conflicting research on whether NSAIDs increase the risk of skin cancer (melanoma). Some studies suggest a higher risk due to their phototoxic effects, while others suggest NSAIDs might protect against skin cancer. A recent systematic review and meta-analysis found no clear link between NSAID use and melanoma. [34]

Diuretics

⚠️ Thiazides (hydrochlorothiazide)

Thiazide diuretics are some of the most commonly prescribed water pills, first introduced in the 1950s to help reduce fluid retention and lower blood pressure. Soon after their release, doctors began reporting photosensitivity reactions in patients taking these medications.

The most commonly reported culprit is hydrochlorothiazide, with over 60 documented cases of people experiencing severe sunburn-like reactions, eczema-like rashes in sun-exposed areas, lichen-like rashes, and dark/light skin discoloration (photoleukomelanoderma). In some cases, chronic eczema-like photosensitivity lasted for months or even years after stopping the drug. Some patients were successfully treated with PUVA therapy (a combination of light therapy and medication).

Studies have shown that both UVA and UVB rays can trigger thiazide-induced photosensitivity, and photopatch testing has confirmed hydrochlorothiazide as a photosensitizer in some cases. However, indapamide, another thiazide-like diuretic, has not been reported to cause skin reactions, although there have been cases of nail damage (photo-onycholysis).

Furosemide, another widely used diuretic, is also linked to sun-induced skin reactions. However, unlike thiazides, furosemide-related photosensitivity usually appears as large blisters (bullous eruptions), sometimes resembling a rare blistering condition called Brunsting-Perry-type bullous pemphigoid. Some studies confirmed this link through rechallenge testing (where patients developed reactions again after taking the drug).

Other less common diuretics, such as triamterene (a potassium-sparing diuretic), have also been reported to cause photosensitivity. [34]

Antiarrhythmics

⚠️Amiodarone

Amiodarone is a strong antiarrhythmic drug that treats and prevents irregular heartbeats, such as ventricular arrhythmias and atrial fibrillation. One possible side effect is photosensitivity.

In some studies, more than 50% of patients taking amiodarone experienced sun-related skin reactions, but newer studies suggest the actual rate is closer to 7%. The typical reaction includes a burning or tingling feeling in sun-exposed areas, followed by redness (erythema) and eczema-like rashes. In some cases, pseudoporphyria (a skin condition that causes blistering and fragility) has also been reported.

After long-term use, 1–2% of patients develop a distinctive blue-gray skin discoloration in sun-exposed areas. This photosensitivity reaction usually fades within months after stopping the drug, but in some cases, it can last longer. Skin discoloration generally fades over 1–2 years. Studies show that both UVA and UVB rays contribute to these reactions.

A newer antiarrhythmic drug called dronedarone is chemically similar to amiodarone but appears to cause much fewer skin reactions. However, some cases of photosensitivity have still been reported.

Another antiarrhythmic, quinidine, has also been linked to sun-related skin reactions, which can appear as eczema-like rashes, lichen-like eruptions, or purplish patches (livedoid purpura). In some cases, quinidine-induced photosensitivity was confirmed through phototesting and photopatch testing (skin tests that check for light-related reactions). [34]

Final Thoughts on Photosensitizing Medications & Red Light Therapy

While red light therapy is generally safe, photosensitive individuals should be cautious. If you are taking any of the medications listed above and experience skin irritation, redness, or burning after RLT, consider whether your medication might be playing a role. When in doubt, consult with your doctor to determine the best course of action.

Bottom Line:

• ✔ RLT is not known to trigger photosensitivity, but certain medications make skin more sensitive to light.
• ✔ If you are taking a strong photosensitizer (⚠️), you may be more prone to irritation.
• ✔ Consult your doctor if you experience unusual skin reactions after RLT, especially if you are on tetracyclines, NSAIDs, or diuretics.

Red Light Therapy in O’Fallon

You can find us at 2717 Hwy K O’Fallon MO, 63368.

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